Page 100 - Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension Onno Anthonius Spruijt
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Age at diagnosis (yrs) Male (%)
6MWT
6MWD (m)
6MWD (% predicted) SaO2-rest (%) SaO2-exercise (%) ΔSaO2 (%)
Laboratory tests NT-proBNP (ng∙L) PCO2 (mmHg) PO2 (mmHg) SaO2 (%)
Baseline hemodynamics HR (beats/min)
mPAP (mmHg)
mRAP (mmHg)
PAWP (mmHg) PVR (dynes∙s∙cm-5) CI (l/min/m2)
SvO2 (%)
Baseline cardiac function LV EDVI (ml/m2)
LV ESVI (ml/m2)
LV EF (%)
RV EDVI (ml/m2) RV ESVI (ml/m2) RV EF (%)
DLCO<43% 65±13 58
286±136 56±23 91±4 79±7 -11 (-16—6)
1004 (304-2487) 30±6 61±15 91±5
80±17 48±12
7 (4-9) 10±3
706 (540-1000) 2.3±0.7
61±9
40±10
15±6
63±10
76±27
54±26
33±12
DLCO 43-62% 53±18*
18
366±119* 70±19* 94±3* 89±6* -4 (-8 –2)*
802 (194-2888) 33±7
DLCO>62% 48±14# 27
416±134# 71±23# 95±2# 89±6#
-5 (-10—2)#
555 (156-1887) 33±6
p-value <0.0001 <0.0001
<0.0001 <0.01 <0.0001 <0.0001 <0.0001
0.45
0.19 <0.05 <0.01
0.84 0.33 0.67 0.27 0.56 0.18 <0.01
<0.05 <0.05 0.21 0.06 0.31 0.67
68±11 72±13# 94±3* 94±3#
78±15 80±13 51±14 52±15
7 (4-11) 9±4
858 (476-1041) 2.5±1.0 63±9
41±11
14±6
66±10
76±17
50±18
36±12
8 (5-11) 8±4
569 (441-961) 2.7±0.9 67±9#
48±13#
18±7†
62±10
88±21
59±23
35±12
Table 1: Baseline characteristics. 6MWD = six minute walking distance; SaO2 = arterial oxygen saturation; HR = heart rate; mPAP = mean pulmonary arterial pressure; mRAP = mean right atrial pressure; PAWP = pulmonary arterial wedge pressure; PVR = pulmonary vascular resistance; CI = cardiac index; SvO2 = mixed venous oxygen saturation; LVEDVI = left ventricular end-diastolic volume index; LVESVI = left ventricular end-systolic volume index; LVEF = left ventricular ejection fraction; RVEDVI = right ventricular end-diastolic volume index; RVESVI = right ventricular end-systolic volume index; RVEF = right ventricular ejection fraction. *DLCO<43% significantly different compared to DLCO 43-62%, #DLCO<43% significantly different compared to DLCO>62%, †DLCO 43-62% significantly different compared to DLCO>62%.
