Page 31 - Risk quantification and modification in older patients with colorectal cancer

Age, ASA score, tumour stage, operative urgency, and albumin were more common predictors for mortality and anastomotic leakage. Six models included parameters such as weight loss12,29,31 and functional status or dependency.13,18,26 Thirteen out of 26 prediction models included intraoperative predictors such as laparoscopic surgery, surgical extent, peritoneal contamination, distance of the anastomosis, duration of surgery , and intraoperative complications such as blood loss.10,15,17,19,21,22,24,25,28-31,34 The proportion of studies that included intraoperative predictors were higher in models with anastomotic leakage as an outcome (5 out of 7)15,19,21,22,29 and the “other outcomes” summarised in Table 2C.17,24,28,30,34 In contrast, only one model for postoperative mortality included intraoperative predictors in their final model.10
Applicability concerns
Shown in Table 3, are the applicability concerns for participant selection, predictors and outcomes for the different studies where they are judged based on their applicability for preoperative shared decision making with older patients. Applicability concerns related to the population were raised for the studies of Pasic et al.19 and Rojas.27 These studies did not describe their study population in more detail or did not include > 30% older patients.
Risk prediction models for CRC patients
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