Page 90 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek
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Chapter 5
Figure 5.2. Patients treated with sodium oxybate (SXB) showed a decrease in body mass index (BMI) during follow-up while patients treated with modafinil did not. P-values are derived from Student’s paired t-tests comparing normalized BMI values at baseline and at last follow-up. Mean follow-up for SXB and modafinil was 2.0 ± 1.7 vs 1.2 ± 1.2 (p = 0.054).
* p < 0.05 † p < 0.01 ‡ p < 0.001
BMI at baseline and medication type influence BMI difference over time
Patients using SXB showed a decrease in BMI that was larger than the BMI deviation of modafinil users (F(1,69.396) = 8.180, p = 0.006). A higher baseline BMI was found to predict a more pronounced BMI decrease (F(1,26.040) = 5.137, p = 0.032). The effect gender had on BMI deviations was found not to be significant (F(1,72.923) = 3.464, p = 0.067). An overview of these and all other main and interaction effects can be found in Table 5.3. Mean values of BMI differences from baseline for four groups based on gender and medication type are depicted in Figure 5.3.
