Page 56 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek
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Chapter 3
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Table 3.4. T cell receptor sequences of 24 (20 narcolepsy type 1 patient, 4 healthy control) H1N1-HA275-287-specific T cell clones (TCCs). Green and red values indicate receptor segments that are shared between TCCs of more than 1 narcolepsy type 1 patient or healthy control.
Study Group Clone TRAV TRAJ number
CDR3
TRBV TRBJ TRBD
CDR3
19 Patient 4 25*01 38*01 19 Patient 8 25*01 38*01 19 Patient 11 25*01 38*01 27 Patient 128 8-6*01 54*01 27 Patient 161 17*01 34*01 27 Patient 161 21*01 43*01 27 Patient 118 25*01 49*01 27 Patient 131 25*01 31*01 27 Patient 145 13-1*01 37*01 27 Patient 145 12-1*01 42*01 27 Patient 125 26-2*01 23*01 38 Patient 108
CAGDAGNNRKLIW CAGDAGNNRKLIW CAGDAGNNRKLIW CAVTSPPIQGAQKLVF CATDAYNTDKLIF CAVVHDMRF CAVNTGNQFYF CAGGNNNARLMF CAPGSGNTGKLIF CVVNDIHYGGSQGNLIF CILRSHYNQGGKLIF
4-2*01 1-4*01 1*01 4-2*01 1-4*01 1*01 4-2*01 1-4*01 1*01 4-2*01 2-1*01 1*01 4-2*01 1-2*01 1*01
CASSHQGINEKLFF CASSHQGINEKLFF CASSHQGINEKLFF CASSQGNGPYNEQFF CASSQASTGGSNYGYTF
50 Patient 9 17*01 34*01 50 Patient 32 17*01 34*01 50 Patient 37 19*01 30*01 50 Patient 38 17*01 37*01 50 Patient 68 12-2*01 26*01 50 Patient 80 17*01 34*01 50 Patient 87 17*01 34*01 50 Patient 99 12-2*01 26*01 102 Control 9 12-2*01/02/03 49*01
102 Control 11 26-2*01 3*01
103 Control 1 12-3*01/02 6*01
103 Control 2 13-1*01 54*01
CATASYNTDKLIF CATASYNTDKLIF CALSEDENRDDKIIF
4-3*01 2-1*01 1*01 4-3*01 1-4*01 1*01
CASSQGGGMGFDEQF CASSRGTAATNEKLF
CAVNKGSNYGQNFVF CATSSYNTDKLIF CATASYNTDKLIF CAVNKGSNYGQNFVF CAVHHTNTGNQFYF CTQSSASKIIF CAMILSGGSYIPTF CAEGGIQGAQKLVF
4-3*01 1-1*01 2*02 6-2*01 1-1*01 1*01 20-1*01 1-5*01 1*01 19*01/02/03 2-5*01 1*01 4-2*01/4-3*01/03/04 2-5*01 1*01 20-1*01/02/03/04/05 1-1*01 1*01
CASSSGRGSMNTEAFF CASSAGTGAFF CSAATGTGETFYNQPQHF CASSRGTGGKETQYF CASSQASGGLGETQYF CSAPKNTEAFF
20-1*01 1-6*01 1*01 20-1*01 2-5*01 1*01 12-3*01 2-5*01 2*01
CSARVGQDSSPLHF CSAAPGLRPQETQYF CASSFQDYPQETQY
3-1*01 1-6*01 1*01 4-1*01 1-1*01 2*02
CASSQSRVSSPLHF CASSQSEGAEAFF
