Page 36 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek

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Chapter 2
Figure 2.1. A. Visualization of HLA-DQB1 allele frequencies that are significantly different between NT1 patients (red) and HLA-DQB1*06:02-positive healthy controls (green). B. Visualization of HLA- DQB1 allele frequencies that are significantly different between pre- (bright red) and post-H1N1 (dark red) NT1 patients.
HLA-DQ2/4/7/8/9 = human leucocyte antigen molecule encoded by the HLA-DQB1*02:01/- DQB1*04:01/-DQB1*03:01 or -03:04/-DQB1*03:02 or -03:05/-DQB1*03:03 allele; NT1 = narcolepsy type 1; * = p < 0.05, ** = p < 0.01, *** = p <0.001.
HLA-DQB1-associations in post-H1N1 NT1 patients with disease onset during childhood are not different than those in other NT1 patients
No significant changes were demonstrated comparing those with disease onset after H1N1 and onset in childhood with all others with NT1 (Supplementary table 2.1).