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Gene ontology category
Term ID
Gene ontology term
Gene count
Genes
Biological Process
GO:0060337
type I interferon signa- ling pathway
9
IRF1, IFI6, OAS2, OAS3, IFI35, MX1, ISG15, GBP2, OAS1
Biological Process
GO:0051607
defense response to virus
10
IRF1, PLSCR1, OAS2, IFI44L, DDX60, OAS3, MX1, ISG15, IL6, OAS1
Biological Process
GO:0006954
inflammatory response
13
CCL20, C3, PLA2G4C, NFKBIZ, TNIP1, RELB, CSF1, PTX3, IL6, NFKB2, CXCL8, TNFAIP6, TNFAIP3
Biological Process
GO:0006955
immune response
13
IL32, CCL20, IFI6, OAS2, LIF, OAS3, C1R, IL6, GBP2, CXCL8, C3, IL7R, OAS1
Biological Process
GO:0045071
negative regulation of viral genome repli- cation
6
TNIP1, PLSCR1, OAS3, MX1ISG15, OAS1
Biological Process
GO:0009615
response to virus
7
OAS2, DDX60, IFI44, OAS3, MX1, IFIH1, OAS1
Biological Process
GO:0060333
interferon-gamma-me- diated signaling pa- thway
6
IRF1, OAS2, OAS3, VCAM1, GBP2, OAS1
Biological Process
GO:0032480
negative regulation of type I interferon pro- duction
4
UBE2L6, IFIH1, ISG15, TNFAIP3
Biological Process
GO:0045087
innate immune res- ponse
9
DDX60, RELB, CSF1, C1R, APOL1, MX1, IFIH1, NFKB2, PTX3
Biological Process
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
13
NFKBIA, IRF1, POU2F2, HELZ2, TNIP1, PARK2, PLSCR1, LIF, IL11, RELB, NAMPT, NFKB2, IL6
Biological Process
GO:0046888
negative regulation of hormone secretion
3
LIF, IL11, IL6
Cellular Compart- ment
GO:0005615
extracellular space
21
IL32, AKR1B1, CCL20, LIF, IL11, CHI3L2, OAS3, NAMPT, ABI3BP, C1QTNF1, C3, PAPPA, TNFAIP2, VCAM1, CSF1, APOL1, STC1, IL6, PTX3, CXCL8, TNFAIP6
Cellular Compart- ment
GO:0005829
cytosol
25
NFKBIA, AKR1B1, IL32, PLSCR1, UBE2L6, PARK2, OAS2, OAS3, AMPD3, NAMPT, ISG15, GBP2, OAS1, IRF1, PLA2G4C, HERC6, BIRC3, IFI35, FHIT, GRIP1, RELB, MX1, IFIH1, NFKB2, TNFAIP3
Molecular Function
GO:0001730
2’-5’-oligoadenylate synthetase activity
3
OAS2, OAS3, OAS1
Molecular Function
GO:0003725
double-stranded RNA binding
5
OAS2, DDX60, OAS3, IFIH1, OAS1
Molecular Function
GO:0005125
cytokine activity
6
IL32, LIF, CSF1, NAMPT, IL6
six
152
Table 1. Enriched gene ontology (GO) terms and associated differential expressed mRNAs as determined by mRNA-sequencing of control and IL-1β stimulated human astrocyte cultures.