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mLST8
Cell membrane
Cytoplasm
Growth factor receptor
PI3K
Growth factors, cytokines,
hormones, glucose, transmitters
IRS
PTEN PDK1
AKT
GATOR1
NPRL3 NPRL2 DEPDC5
FKBP Rapalogs
TSC1
TBC1D7 TSC2 AMPK
Rheb
mTORC1 Raptor
STRADα LKB1
mTOR PRAS40 Deptor
Transcription Autophagy
Growth of fetal brain
Proliferation and migration Axon elongation
Dendrite formation
HIF1α
VEGF
Angiogenesis
S6K1
S6
Cell growth
4E-BP1
eIF4E
Translation
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