Page 97 - Human Bile Acid Metabolism: a Postprandial Perspective

A 8
6 4 2
†
B 800 600 400 200
Short term starvation and bile acid supplementation
Finally, postprandial excursion of the BA/FXR-induced enterokine FGF19 was not affected by gDCA administration (AUC0-240 –gDCA: 48.8 [16.9] ng/mL × min vs. +gDCA: 46.7 [12.9] ng/mL × min, P > 0.05, 2-way RM-ANOVA P > 0.05) (Fig. 2D). We found no correlations between BAs, GLP-1, and FGF19 (data not shown). The iAUCs of both GLP-1 and FGF19 yielded the same results (data not shown).
00
0 60 120 180 240 0 60 120 180 240 5 Time (min) Time (min)
†
CD 2.0
0.5 0.4 0.3 0.2 0.1
0.0 0 60 120 180 240
1.5 1.0 0.5
0.00 60 120 180 240
Time (min)
E
20 10 0
†
20 15 10 5 0
Time (min)
120 180 240
Time (min)
40
30 -5 -10
Time (min)
Fig. 3. Postprandial glucose homeostasis after oral glycine-conjugated deoxycholic acid (gDCA) administration in healthy men. In a crossover design, healthy men (n = 10) consumed a standardized liquid meal test at t = 0 with or without 750 mg gDCA. Postprandial excursion of glucose (A), insulin (B), gDCA (C), fibroblast growth factor 19 (FGF19; D), and (incremental) glucagon-like peptide 1 (GLP-1; F). , –gDCA; ●, +gDCA. † at the curve represents significant effect on area under the curve. Data are means ± SE.
60
- gDCA + gDCA
95
GLP-1 (pmol/L)
GLP-1 (pmol/L)
Insulin (pmol/L)
gDCA ( mol/L)
Glucose (mmol/L)
FGF19 (ng/mL)