Page 76 - Human Bile Acid Metabolism: a Postprandial Perspective

Chapter 4
Table 2: Bilogram and FGF 19.
Bile acid fraction
Total bile acids (mmol/L)
Total CA (mmol/L)
Total CDCA (mmol/L)
Total DCA (mmol/L)
Total Glycine-conjugated BA (mmol/L) Total Taurine-conjugated BA (mmol/L) Total unconjugated BA (mmol/L)
Total 6 BA (mmol/L) FGF19 (ng/mL)
Pre-VLCD
baseline 0.80 (1.25) peak 3.80 (3.32) AUC 517 (400) baseline 0.10 (0.18) peak 0.60 (0.90) AUC 92 (81) baseline 0.40 (0.38) peak 2.00 (1.80) AUC 257 (226) baseline 0.25 (0.28) peak 0.90 (0.90) AUC 146 (139) baseline 0.30 (0.40) peak 2.90 (2.68) AUC 357 (314) baseline 0.00 (0.15) peak 0.35 (0.53) AUC 64 (49) baseline 0.30 (0.58) peak 0.65 (0.98) AUC 91 (195) baseline 0.40 (0.80) peak 1.65 (1.53) AUC 242 (185) baseline 0.09 (0.06) peak 0.29 (0.30) AUC 56.5 (46.0)
Post-VLCD p
1.05 (1.08) 0.87 4.05 (2.95) 0.46 517 (227) 0.72 0.15 (0.28) 0.75 0.85 (0.88) 0.82 65 (129) 0.94 0.40 (0.55) 0.54 2.00 (1.53) 0.70 231 (79) 1.00 0.30 (0.53) 0.12 1.25 (1.35) 0.045* 162 (149) 0.23 0.55 (0.55) 0.53 2.60 (2.68) 0.67 313 (87) 0.75 0.00 (0.10) 0.75 0.40 (0.80) 0.51 53 (48) 0.79 0.50 (0.55) 0.64 1.05 (1.83) 0.72 146 (188) 0.70 0.45 (1.53) 0.58 2.50 (2.30) 0.39 237 (269) 0.43 0.10 (0.11) 0.26 0.32 (0.28) 0.91 40.8 (34.2) 0.31
Values are presented as median (IQR). The unit of bile acid peak and baseline values is mmol/L, the unit of AUC is mmol min L-1. P-values were calculated using the related-samples Wilcoxon Signed Rank test. * denotes p < 0.05.
Table 3: Indirect calorimetry.
Pre-VLCD REE/kg kcal
REE total kcal
RQ
Post-VLCD fasting
1.5 h postprandial 4 h postprandial fasting
1.5 h postprandial 4 h postprandial fasting
1.5 h postprandial 4 h postprandial
p
17.9 (7.2)
22.8 (6.1)
19.1 (6.4)
1938 (736)
2210 (594)
2047 (638)
0.84 (0.08)
0.83 (0.06)
0.82 (0.04)
were calculated using the related
0.04 0.02 0.03 0.03 0.02 0.03 0.12 0.65 0.35
samples Wilcoxon Signed
Values are presented as median (IQR). P-values Rank test.
74
18.0 (4.3) 20.2 (2.8) 18.6 (4.0) 1810 (356) 1959 (273) 1859 (377) 0.79 (0.06) 0.79 (0.07) 0.81 (0.04)