Page 37 - Advanced echocardiography in characterization and management of patients with secondary mitral regurgitation

Follow-up
During follow-up, two-thirds of the patients (64%) received cardiac resynchronization therapy, and 308 patients (44%) received mitral valve intervention: 28% underwent surgical mitral valve repair and 16% received transcatheter edge-to-edge mitral valve repair. Men more frequently received cardiac resynchronization therapy when compared to women. In terms of invasive mitral valve treatment, women more often underwent surgical mitral valve repair (34%), whilst no differences were observed in transcatheter edge-to-edge mitral valve repair. A summary of device implantation and mitral valve intervention at follow-up and differences between men and women is shown in Table 3.
Table 3. Intervention during follow-up.
Device therapy, n (%) Cardiac resynchronization
therapy
MV intervention, n (%) Medical therapy only Mitral valve repair
Mitral valve replacement MitraClip
Total population (n= 698)
414 (64)
387 (55) 198 (28) 3 (0.4) 110 (16)
Men (n= 471)
294 (68)
279 (59) 122 (26) 1 (0.2) 69 (15)
46 (10) 83 (18)
12 (3) 39 (8)
Women (n= 227)
120 (55)
108 (48) 76 (34) 2 (0.9) 41 (18)
14 (6) 46 (21)
5 (2) 24 (11)
p-value
0.001
0.004 0.037 0.206 0.246
0.112 0.264
0.782 0.322
Concomitant procedure, n (%) *
CABG
Tricuspid valve annuloplasty
LV reconstruction
Cardiac support device (CoreCap)
60 (9) 131 (19)
17 (2) 63 (9)
MAZE
Continuous data are presented as mean ± SD or median [interquartile range]. Categorical data are presented as numbers and percentages. * Concomitant procedures with mitral valve treatment.
CABG, coronary artery bypass graft
Survival analysis
During a median follow-up of 57 [interquartile range 29-110] months, 373 (53%) patients died. Women showed significantly lower mortality rates at 1-, 2- and 5-years follow-up as compared to men (women 9%, 16% and 33% vs. men 10%, 20% and 42%, respectively; P= 0.001, Figure 1, panel A). Based on the Kaplan-Meier curves, an additional landmark analysis was performed at 36 months of follow-up demonstrating
30 (4)
21 (5)
9 (4)
0.763
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