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Chapter 250suitable alternative for RCTs. We provide recommendations to enhance methodological and statistical quality as well as generalizability, feasibility, and personalization. Future use of this N-of-1 framework will assist in realizing the sorely needed evidence-based interventions for these vulnerable patients.Authors’ contributionsAM was involved in the study concept and design, had a major role in the acquisition of data, analysis and interpretation of data, drafted the manuscript. MB was involved in the study concept and design, had a major role in the acquisition of data, revised the manuscript for content. PvdV and MC were involved in the study concept, had a major role in the acquisition of data, analysis or interpretation. KR was involved in the study concept, design, and analysis or interpretation of data. CvK and FW were involved in the study concept and design, and revised the manuscript for content. JD conducted the search strategy and contributed to the analysis and interpretation of data. EB was involved in the study concept and design, had a major role in the acquisition of data, analysis and interpretation, revised the manuscript for content, including medical writing. AvE was involved in the study concept and design, had a major role in the acquisition and interpretation of data, drafted and revised the manuscript for content, including medical writing.Annelieke Muller sHL.indd 50 14-11-2023 09:07