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N-of-1 studies in rare genetic neurodevelopmental disorders352Figure 2. PRISMA Flowchart.PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analysis.method of primary and/or secondary analysis (qualitative, graphical, tabular, (non)parametric statistics, and Bayesian statistics), main results, suggested inference, and challenges. The interventions were classified into disease-modifying or symptomatic, using a standard definition of diseasemodifying: an intervention mediating the effect by targeting the primary underlying pathophysiology and changing the course of the disease with an enduring effect.24 The suggested inference appraised generalization of the study’s outcomes to either the individual participants or patients in general with that specific disorder. Generalization measures were defined Annelieke Muller sHL.indd 35 14-11-2023 09:07