Page 56 - Demo

54Chapter3ABSTRACTCraniosynostosisisacongenitaldefect whichcanresultinabnormalcranialmorphology Threedimensional(3D)stereophotogrammetryispotentiallyanidealtechniquefortheevaluationofcranialmorphologyanddiagnosisof craniosynostosisbecauseitis fast andharmless This studypresents anewmethodforobjectivecharacterizationofthemorphologicalabnormalitiesofscaphocephalyandtrigonocephalypatientsusing3DphotographsofpatientsandhealthycontrolsSixty3Dphotographsofhealthycontrolsintheagerangeof3–6monthsweresuperimposedandscaledPrincipalcomponentanalysis(PCA)wasappliedtofindthemeancranialshapeandthecranialshapevariationinthisnormalpopulation3Dphotographsof20scaphocephalyand20trigonocephalypatientswereanalysedbythisPCAmodeltotestwhethercranialdeformitiesofscaphocephalyandtrigonocephalypatientscouldbeobjectivelyidentifiedPCAwasusedtofindthemeancranialshapeandthecranialshapevariationinthenormalpopulation ThePCAmodelwasabletosignificantlydistinguishscaphocephalyandtrigonocephalypatientsfromthenormalpopulation3Dstereophotogrammetryincombinationwiththepresentedmethodcanbeusedtoobjectivelyidentifyandclassifythecranialshapeofhealthynewbornsscaphocephalyandtrigonocephalypatients