Page 127 - Physiological based CPAP for preterm infants at birth Tessa Martherus

Feasibility and effect of physiological based CPAP in preterm infants at birth
There were no significant differences in the number of infants receiving caffeine (25% vs 55%, p=0.221) or iPPV (75% vs 55%, p=0.419), yet the duration of mask ventilation was significantly shorter in those supported with PB-CPAP (0:42 (0:34-2:22) min) as compared to 5-8 cmH2O CPAP (2:58 (1:36-6:03) min, p=0.020). In the PB-CPAP group, two infants started to breathe spontaneously during mask ventilation and continued afterwards until CPAP was increased back to 15 cmH2O. These infants then stopped breathing and required interventions to re-start spontaneous breathing.
Outcomes reflecting the infant’s overall stability (Table 2)
The groups showed similar Apgar scores at 5 and 10 min after birth. Infants were considered stable after 6:36 (5:49-11:03) min in the PB-CPAP group and 9:57 (6:58-15:06) min in the 5-8 cmH2O CPAP group (p=0.256).
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Figure 3. Physiological outcomes. Physiological outcomes a) oxygen saturation (SpO2), b) fraction of inspired oxygen (FiO2), c) heart rate and d) time that heart rate exceeds 100 bpm of infants receiving PB-CPAP and 5-8 cmH2O CPAP following the per-protocol analysis. In Figure 3D, heart rate >100 bpm is illustrated as the incidence over time (continuous line) with the median group time (dotted vertical line) and (shaded) inter quartile range.
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