Page 125 - Physiological based CPAP for preterm infants at birth Tessa Martherus

Feasibility and effect of physiological based CPAP in preterm infants at birth
Table 1 shows baseline characteristics for both groups. Infants in the PB-CPAP group had a median (IQR) gestational age of 26+5 (25+4-27+4) weeks, whereas infants in the 5-8 cmH2O group were 28+5 (25+4-29+4) gestational age (p=0.601). There were no statistical differences with regard to birth weight, gender, mode of delivery and the use of antenatal steroids. The number of twin pregnancies was significantly higher in the 5-8 cmH2O CPAP group (50%) as compared to the PB-CPAP group (0%, p=0.025). There were no significant differences regarding maternal medication use, complications that occurred during the pregnancy or physiological based cord clamping that could have affected the respiratory effort at birth. Apgar scores at 1 min were similar between groups.
Table 1. Demographical data (per-protocol) Gestational age at birth (weeks) a
Birth weight (grams) a
Gender (% male) b
Type of pregnancy (n, % twin) (b)
Mode of delivery (n, % caesarean section) b Antenatal steroids
Course started (n, %) b
Course completed (n, %) b
Maternal medication use influencing infants respiration e.g. general anaesthesia (n, %) b Complications during pregnancy (n, %) b
Preterm prelabour rupture of membranes (n, %)
Pregnancy-induced hypertension (n, %) Intra-uterine infection (n, %) Intra-uterine growth restriction (n, %) Multiple (n, %)
Physiological based cord clamping (n, %) b
P
PB-CPAP 5-8 cmH2O CPAP (n=8) (n=20)
P- value
26+5 (25+4-27+4) 1022 (835-1255) 5 (63%)
0 (0%)
1 (13%)
8 (100%) 6 (75%) 0 (0%)
3 (38%) 2 (25%)
1 (13%) 1 (13%) 0 (0%) 1 (13%) 3 (38%) 6 (2-7)
28+5 (25+4-29+4) 935 (757-1180) 12 (60%)
10 (50%)
10 (50%)
18 (90%) 13 (65%) 1 (5%)
11 (55%) 6 (30%)
4 (20%) 5 (25%) 3 (15%) 7 (35%) 5 (25%) 6 (3-8)
0.601 0.409 1.000 0.025 0.099
1.000
1.000
1.000 5
0.678
0.651
Apgar score ‘1 a
Demographical data analysed as per-protocol. Numerical data presented as median (Q1-Q3) compared using a a) Kruskal-Wallis test. Categorical data presented as n, (%) compared using a b) Fisher’s exact test.
0.823
121
r