Page 313 - Personalised medicine of fluoropyrimidines using DPYD pharmacogenetics Carin Lunenburg

Nr. Marker Chr
16 rs56338926 15
17 rs449973 3
18 rs1722291 7
19 rs2344989 17
20 rs2512155 11
21 rs8076418 17
22 rs2738545 16
23 rs10851447 15
24 rs722910 5
25 rs8070810 17
26 rs8067883 17
27 rs6501582 17
28 rs113309475 1
29 rs9911437 17
30 chr17:70923098:D 17
Position
75259335
21425977
56238936
70924851
117889448
70921917
78629320
47411086
52781597
70921851
70921731
70921801
11430624
70922305
70923098
A0 A1
C A C G G A T C C T T C G A T A A T G A C T T C A T T C AC A
AF β
0,448 0,772401797 0,548 1,69493935 0,198 1,553925389 0,04 1,54932572 0,179 1,449722565 0,042 1,608309687 0,673 0,420462271 0,059 1,464774341 0,496 0,35577388 0,042 1,61395951 0,042 1,612564569 0,042 1,613613576 0,023 1,200617555 0,042 1,614540275 0,042 1,614669511
P-value
7,94E-06 7,97E-06 8,02E-06 8,33E-06 8,45E-06 8,5E-06 9,13E-06 9,21E-06 9,36E-06 9,42E-06 9,43E-06 9,44E-06 9,49E-06 9,49E-06 9,65E-06
Abbreviations: Nr: number; Chr: chromosome; A0: nucleotide on allele 0; A1: nucleotide on allele 1; AF: allele frequency.
Figure 4. PRS-plot
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Genome-wide association study
The PRS-plot shows the predictive power of a covariate model (Clinical, blue line) and a covariate model plus 5,055 SNPs (PRS, red line). Included clinical parameters were gender, age, baseline BSA and treatment schedule. The AUC for the covariate model is 0.620 (95%CI: 0.577-0.663, p=1.34-09), compared to the AUC for the combined model (prs) 0.956 (95%CI: 0.939-0.973, p=3.98-140). Abbreviations: PRS: polygenic risk score; AUC: area under the curve; 95%CI: 95% confidence interval.
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