Page 122 - Personalised medicine of fluoropyrimidines using DPYD pharmacogenetics Carin Lunenburg

Chapter 4
DPYD:
wildtype/*13 wildtype/c.1236G>A wildtype/c.2846A>T
DPYD:
*2A/*2A c.1236G>A/c.1236G>A c.2846A>T/c.2846A>T
DPYD:
*2A/*2A wildtype/c.1236G>A c.2846A>T/c.2846A>T
DPYD:
*2A/*2A c.1236G>A/c.1236G>A wildtype/c.2846A>T
DPYD:
*2A/*2A wildtype/c.1236G>A wildtype/c.2846A>T
DPYD:
*2A/*2A
*13/*13 c.1236G>A/c.1236G>A
DPYD:
*2A/*2A
*13/*13 wildtype/c.1236G>A
DPYD:
*2A/*2A
*13/*13 c.2846A>T/c.2846A>T
DPYD:
*2A/*2A
*13/*13 wildtype/c.2846A>T
DPYD:
*2A/*2A
wildtype/*13 c.1236G>A/c.1236G>A
DPYD:
*2A/*2A wildtype/*13 wildtype/c.1236G>A
DPYD:
*2A/*2A wildtype/*13 c.2846A>T/c.2846A>T
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
G:G
T:G*13
G:A c.1236G>A A:T c.2846A>T
A:A *2A
T:T
A:A c.1236G>A T:T c.2846A>T
A:A *2A
T:T
G:A c.1236G>A T:T c.2846A>T
A:A *2A
T:T
A:A c.1236G>A A:T c.2846A>T
A:A *2A
T:T
G:A c.1236G>A A:T c.2846A>T
A:A *2A
G:G *13
A:A c.1236G>A A:A
A:A *2A
G:G *13
G:A c.1236G>A A:A
A:A*2A G:G*13
G:G
T:T c.2846A>T
A:A*2A G:G*13
G:G
A:T c.2846A>T
A:A*2A T:G*13
A:A c.1236G>A A:A
A:A *2A
T:G *13
G:A c.1236G>A A:A
A:A *2A
T:G *13
G:G
T:T c.2846A>T
Unable to predict the gene activity score (GENE ACTIVITY SCORE 0 to 1). Phenotyping should distinguish which variants are present on the same allele. The activity of an allele with the two variants c.1236G>A and c.2846A>T is not known, because it
is not known whether the variants have an independent or synergistic effect or whether the second variant does not have an additional effect.
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
GENE ACTIVITY SCORE 0
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table continues