Page 119 - Personalised medicine of fluoropyrimidines using DPYD pharmacogenetics Carin Lunenburg

Supplement
DPYD: WILDTYPE/*2A WILDTYPE/c.2846A>T
DPYD:
WILDTYPE/*13 WILDTYPE/c.1236G>A
DPYD:
WILDTYPE/*13 WILDTYPE/c.2846A>T
DPYD: WILDTYPE/c.1236G>A WILDTYPE/c.2846A>T
DPYD: c.1236G>A/c.1236G>A c.2846A>T/c.2846A>T
DPYD: WILDTYPE/c.1236G>A c.2846A>T/c.2846A>T
DPYD: c.1236G>A/c.1236G>A WILDTYPE/c.2846A>T
DPYD:
*13/*13 c.1236G>A/c.1236G>A
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
DPYD_rs3918290 DPYD_rs55886062 DPYD_rs56038477 DPYD_rs67376798
G:A *2A
T:T
G:G
A:T c.2846A>T
G:G
T:G*13
G:A c.1236G>A A:A
G:G
T:G*13
G:G
A:T c.2846A>T
G:G
T:T
G:A c.1236G>A A:T c.2846A>T
G:G
T:T
A:A c.1236G>A T:T c.2846A>T
G:G
T:T
G:A c.1236G>A T:T c.2846A>T
G:G
T:T
A:A c.1236G>A A:T c.2846A>T
G:G
G:G *13
A:A c.1236G>A A:A
Unable to predict the gene activity score. Phenotyping should distinguish if both variants are present on separate alleles (GENE ACTIVITY SCORE 0.5) or on the same allele (GENE ACTIVITY SCORE 1).
Unable to predict the gene activity score. Phenotyping should distinguish if both
variants are present on separate alleles
(GENE ACTIVITY SCORE 0.5) or on the same
allele (GENE ACTIVITY SCORE 1). 4
Unable to predict the gene activity score. Phenotyping should distinguish if both variants are present on separate alleles (GENE ACTIVITY SCORE 0.5) or on the same allele (GENE ACTIVITY SCORE 1).
Unable to predict the gene activity score. Phenotyping should distinguish if both variants are present on separate alleles (GENE ACTIVITY SCORE 1) or on the same allele (GENE ACTIVITY SCORE 1 to 1.5). When both variants are located on the same allele, it is not known whether the variants have an independent or synergistic effect or whether the second variant does not have an additional effect.
Unable to predict the gene activity score (GENE ACTIVITY SCORE 0 to 1). Both variants are located on the same allele, but it is not known whether the variants have an independent or synergistic effect or whether the second variant does not have an additional effect.
Unable to predict the gene activity score (GENE ACTIVITY SCORE 0.5 to 1). There is one allele with one variant and one allele with two variants, but it is not known whether the two variants on the same allele have an independent or synergistic effect or whether the second variant does not have an additional effect.
Unable to predict the gene activity score (GENE ACTIVITY SCORE 0.5 to 1). There is one allele with one variant and one allele with two variants, but it is not known whether the two variants on the same allele have an independent or synergistic effect or whether the second variant does not have an additional effect.
GENE ACTIVITY SCORE 0
table continues
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