Page 131 - Migraine, the heart and the brain

Cerebellar function and ischemic brain lesions in migraine
Figure 4. Body-sway measurements during one task of two-legged stance condition (two legs with eyes closed on foam) for individual participants. Panels show pitch angle vs roll angle (top row), pitch angle velocity vs roll angle velocity (middle row), and angles for roll and pitch over time (bottom row) for a healthy control, migraineur with aura, migraineur without aura and FHM1 patient, from left to right, respectively. Note that for all parameters controls and migraine patients are similar, whereas the FHM1 patient stands out showing deviations and instability. FHM1: familial hemiplegic migraine type 1.
disCussion 7
We tested the hypotheses (i) that migraine is associated with cerebellar dysfunction and (ii) that this might be due to increased prevalence of cerebellar ischaemic lesions. To this end we systematically assessed motor and non-motor cerebellar function of unselected but well-de ned migraine patients with or without aura from the general population by using an array of sensitive and validated tests covering all main functions of the cerebellar cortex. In addition, all participants underwent brain MRI to screen for cerebellar lesions. Results were compared with those obtained in non-migraine controls and, as a positive control, participants with genetically proven FHM1. Whereas participants with FHM1 performed worse compared both to controls and participants with non-hemiplegic migraine on the primary outcomes of all behavioural tests, participants with non-hemiplegic migraine did not differ from non-
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