Page 197 - Functional impairment and cues for rehabilitation of head and neck cancer patients -

Figure 1 Delineated CT-slide at C3 level
Statistical analysis
Analyses were performed using IBM® SPSS® Statistics 23.0 and R 3.3.2 (40, 41). P values < .05 were considered statistically significant. Univariable Poisson regression analysis with a log link was used to assess the crude and adjusted associations of neck SMI and prolonged feeding tube dependency in this sample, which we report as risk ratios (RR), with 95% confidence intervals (CI) and corresponding p values based on robust (sandwich) errors (42).
In the multivariable analysis, the relationship was estimated adjusting for the most relevant confounders. During a consensus meeting a Directed Acyclic Graph (DAG) was constructed to identify potential confounders and mediators (see Figure 2). From the available data, potential confounders and mediators were chosen based on information from previous studies, and expert opinion. The DAG indicated that, to estimate the direct effect of SMI on prolonged feeding tube dependency, the minimal set of adjustment covariables included BMI, FOIS, and SES. To assess the extent to which the effect of neck SMI of prolonged feeding tube dependency was mediated by BMI, the relation was also estimated without adjusting for BMI.
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Sarcopenia as determinant for tube dependency
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