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CONCLUSIONS
In this article, we demonstrated that PFF induces substantial changes in osteoblast cell and nucleus morphology and volume, which are accompanied by altered spatial and temporal distribution of adhesion and cytoskeletal proteins. More insights into the mechanisms driving morphological changes in bone cells, and thereby, possibly bone cell behavior, in response to mechanical cues, will aid the guidance of clinical treatment, particularly in the field of orthodontics, (oral) implantology, and orthopedics.
ACKNOWLEDGEMENTS
The authors thank Gerard de Wit for western blotting. This work was granted by the China Scholarship Council (CSC, No. 201608530156).
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