Page 105 - Effects of radiotherapy and hyperbaric oxygen therapy on oral microcirculation Renee Helmers

Late radiation-induced oral microvascular changes
Table 1. Continued
Patient demographics [N=30]
Intoxication
Smoking history
Cancer therapy
Chemoradiation
Only RT
Mean RT dosage buccal mucosa Mean RT dosage gingiva
Time since RT
Healthy controls [N=30]
Age
Gender Dental status
Basic hemodynamics
HR
SBP
DBP
MAP [mmHg] 99 ±9 5
COPD = chronic obstructive pulmonary
mean arterial pressure; RT = radiation therapy; SBP = systolic blood pressure; SD = standard deviation
Angioarchitecture
Buccal and gingival angioarchitecture classifications are presented in Figure 1. Only class 1 was observed in control subject tissues. Irradiated sites presented all class types [Table 2]. Sample images of healthy buccal and gingiva microcirculation are presented in Figure 2. The observed differences in irradiated buccal mucosa were altered capillary loops with telangiectasia- like (ballooning) and loss in normal arrangement of capillary loop organization [Fig. 3]. All observed pathologic microvasculature appeared hemodynamically functional with good blood circulation present in all vessels of the buccal mucosa and gingiva.
Mean SD
34 ± 12 49 ± 17 4 ± 5
Mean SD
[yrs]
[F:M] 11:19 [edent.:dentate] 0:30
N (%) 4 (13%)
N (%)
12 (40%) 18 (60%) [Gy]
[Gy] [yrs]
[bpm] [mmHg] [mmHg]
73 ±2 132 ±14 82 ±8
51 ±4
disease; DBP = diastolic blood pressure; HR = heart rate; MAP =
103