Page 104 - Effects of radiotherapy and hyperbaric oxygen therapy on oral microcirculation Renee Helmers

Chapter 5
was used for this data. IBM SPSS Statistics software package (IBM® SPSS® Statistics version 24, IBM Corp. Armonk, NY, USA) was used to perform all data analyses. All data are presented as means±standard deviation (SD) and significance level was confirmed if p-values were <0.05.
RESULTS
Both patients and control subjects easily complied with microcirculation measurements, as they were noninvasive and painless. Even patients that experienced preexisting discomfort associated with their underlying pathology, such as trismus, were able to tolerate the measurements well. Patient and control participant demographics and hemodynamic parameters are presented in Table 1. The images acquired with the CC were of excellent quality as the buccal and gingival tissues were able to provide sufficient contrast with the microcirculation to gain clear high-resolution images (CC brightness=450 in all measurements). Four clips were obtained per ROI (16 total) in each participant, a total of 960 clips were analyzed in this study.
Table 1. Patient and control demographics and hemodynamic parameters for controls.
Patient demographics [N=30]
Age
Gender Dental status
Site of radiation
Oral cavity Oropharynx Hypopharynx Nasopharynx Larynx
Other
Oral lesion presence
Co-morbidities
Diabetes Hypertension COPD
Mean SD
102
[yrs]
[F:M] 8:22 [edent.:dentate] 9:21
N (%) 10 (33%) 8 (27%) 1 (3%)
4 (13%) 5 (17%) 2 (7%)
5 (17%)
N (%)
1 (3%) 3 (10%) 3 (10%)
61 ± 10