Page 62 - Postoperative Intra-Abdominal Adhesions- New insights in prevention and consequences

Chapter 3
In the control and icodextrin 4% groups histological examination of the abdominal wall after two weeks showed an inflammatory reaction grade 1. In addition, a small layer of new mesothelial cells was visible in all cases. In the PVA/CMC group remains of the gel were still visible after two weeks combined with an inflammatory reaction grade 2 (figure 3). For comparison an example of a histology sample of the control group is shown in figure 4. No icodextrin 4% was found in any of the histological samples.
Fig. 3. Experiment 2, PVA/CMC compared to icodextrin: histological examination (lOOx) of the abdominal wall after 2 weeks. PVA/CMC gel residues were present (black arrows).
Experiment 3:
Histological examination of the abdominal wall after four as well as after six weeks revealed the formation of neo-peritoneum in all cases. An inflammatory reaction grade 1 was still visible in all animals, although more prominent in the four week than in the six week samples. After meticulous microscopic examination no PVA/CMC gel or icodextrin 4% residues were visible in any sample after four and six weeks.
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