Page 220 - 18F-FDG PET as biomarker in aggressive lymphoma; technical and clinical validation
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Chapter 8
Optimal timing for I-PET scans
HRs were lowest for I-PET1 and increased for later PET scans with highest HRs at I-PET4 for all criteria. HRs at I-PET3 were lower than HRs for I-PET2 using ∆SUVmax and DS5 to define PET response. NPV was high for all criteria at both I-PET 2 and I-PET4 (range, 80.0% to 84.7%; Table 2). The PPV was higher at I-PET4 than at I-PET2 for DS4-5 (42.6% and 30.5%), DS5 (70.0% and 68.5%), and ∆SUVmax (57.4% and 45.7%) criteria.
Figure 4. Two-year PFS Cox regression stratified for DS5 I-PET-positive patients and timing.
Corrected for low-risk (A), low-intermediate risk (B), high-intermediate risk (C), and high-risk (D) IPI
groups. For all risk groups, I-PET2-positive and I-PET3-positive regression curves are superimposed.
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