Page 218 - 18F-FDG PET as biomarker in aggressive lymphoma; technical and clinical validation

Chapter 8
of I-PET scans using DS4-5 response criteria was 2.20 (95% CI, 1.79-2.69). The univariable HR of IPI scores for the entire study population was 2.91 (95% CI, 2.34-3.61). When selecting patients age 60 years or younger, the univariable HR of IPI score was 2.46 (95% CI, 1.76-3.44) vs 2.58 (95% CI, 1.83-3.66) for the aaIPI prognostic score.
I-PET2 and I-PET4 significantly discriminated good responders and poor responders (Table 1), with higher HRs for I-PET4 for a PET positive result using DS4-5–positive (HR, 1.71 and 2.95; Figure 3), DS5-positive (HR, 4.91 and 6.20; Figure 4), and ∆SUVmax (HR, 2.93 and 4.65; Figure 5) criteria. Unlike I-PET1, I-PET3 discriminated good responders and poor responders using DS4-5 and DS5 PET response criteria (HR, 2.94 and 4.67) but not ∆SUVmax.
Figure 2. PFS from day of baseline scan for individual studies included in our analysis.
(A) Kaplan-Meier survival curve for 5-year PFS for all studies. (B) Uncorrected Cox regression 2-year PFS
for all studies. (C) Cox regression corrected for IPI score for 2-year PFS for all individual studies. 216