Page 188 - 18F-FDG PET as biomarker in aggressive lymphoma; technical and clinical validation
P. 188
Chapter 7
Figure 1. Disposition of the patients.
Eighty-two patients were included. In 14 patients, MYC fluorescence in situ hybridization (FISH) was performed immediately at diagnosis, these patients started with R2CHOP (lenalidomide in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) in cycle 1. In 68 patients, MYC results became available during the first cycle of R-CHOP; these patients were registered after the first cycle of R-CHOP and started with R2CHOP in the second cycle and continued lenalidomide for 14 days after the sixth cycle of R-CHOP. During treatment 13 patients went off protocol (progressive disease [n=7], toxicity [n=2; pulmonary embolism and diarrhea], other reasons [n=3; new diagnosis of colon cancer, patient refusal, and vertebral fracture]). R: rituximab, R2: rituximab + lenalidomide.
186
