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Table 1. Continued
Bone Marrow involvement
yes
no
not done
IPI
N%
16 20 4454 22 27
R-CHOP with lenalidomide in MYC+ LBCL
Low 12 15 Low-intermediate 17 21 High-intermediate 32 39 High 21 26
Morphology (WHO2008)
DLBCL 65 79 BCL-U 12 15 indecisive between DLBCL or BCL-U 5 6
COO IHC (Hans classification)
GCB subtype 63 77 Non-GCB subtype 8 10 Not evaluable 11 13
COO GEP (Nanostring) n=38
GCB subtype 29 76 ABC subtype 7 18 Intermediate 2 5
FISH analysis
single hit 20 24 double hit 44 54 MYC+/BCL2+ 31*
MYC+/BCL6+ 13**
Triple hit 9 11 MYC+ (BCL2 and BCL6 status unknown) 9 11
Demographics and disease characteristics of 82 MYC+ LBCL patients treated with R2CHOP. LBCL: large B-cell lymphoma; DLBCL: diffuse large B-cell lymphoma; WHO: World Health Organisation; R-CHOP: rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone; FISH: fluorescence in situ hybridization, LDH: lactate dehydrogenase, ULN: upper limit of normal; GCB: germinal center B-cell subtype; COO: cell-of-origin; IHC: immune-histochemistry; GEP: gene expression profiling; BCL-U; B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma *from 4 of these patients BCL6 status is unknown, **from 1 of these patients BCL2 status is unknown.
Pathology review
Diagnostic biopsy samples of all 85 patients were available for pathology review. Results of all 82 eligible patients are summarized in Table 1 and the Online Supplementary Table S2. A diagnosis of DLBCL according to the WHO 2008 classification was confirmed in 65 of 82 patients (79%) and BCL-U in 12 of 82 patients (15%) and morphology was indecisive between DLBCL and BCL-U in 5 of 82 patients (6%). For classification according to the WHO classification 2017 see the Online Supplementary Table S2. In 81 of 82 patients MYC rearrangement was confirmed at central review. Based on the intention to treat principle, the one patient in whom MYC rearrangement could not be confirmed was included
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