Page 95 - Fertility in Women with Rheumatoid Arthritis Vruchtbaarheid van vrouwen met reumatoïde artritis

Table 2 - The association of anti-Müllerian hormone (AMH) levels (log-transformed) with disease related factors in women with rheumatoid arthritis (n=209)
Age -
-0.061 0.44 0.22 0.0076 -0.18 0.76 0.30 -0.14 ** -0.47 0.14 0.0080 0.36 -0.14 0.35 -0.001 0.34 -0.010 0.50 0.18 0.47 0.095
Never been pregnant before Disease duration - per year RF positivity
ACPA positivity
DAS28-CRP - per point Presence of erosions NSAIDs preconceptional Prednisone preconceptional Sulfasalazine
Past use of methotrexate
0.13 -0.022 0.30 -0.57 0.001 -0.085 0.010 -0.0004 0.17 0.11
-0.19 ‒ -0.053 ‒ -0.15 ‒ -0.99 ‒ -0.14 ‒ -0.53 ‒ -0.33 ‒ -0.34 ‒ -0.16 ‒ -0.25 ‒
-0.18 ‒ 0.47 0.15
-0.29 ‒ Uncorrected for age
0.40 0.036
AMH in RA – time to pregnancy
Variable
Monovariable associations
Age - per year
Never been pregnant before Disease duration - per year RF positivity
ACPA positivity
DAS28-CRP - per point Presence of erosions NSAIDs preconceptional Prednisone preconceptional Sulfasalazine
Past use of methotrexate
Multivariable analysis
Beta
-0.070 0.16 -0.022 -0.040 -0.38 -0.012 -0.24 0.040 0.031 0.14 0.053
95% con dence interval
Uncorrected for age
Beta
95% con dence interval
Corrected for age
-
Association with log(AMH)
-0.11 ‒
-0.15 ‒ -0.048 ‒ -0.40 ‒ -0.71 ‒ -0.15 ‒ -0.61 ‒ -0.28 ‒ -0.29 ‒
-0.031 **
0.47 0.33 0.004 -0.018 0.32 0.033 -0.056 * -0.29 0.12 -0.0020 0.14 -0.25 0.36 0.021 0.35 0.014
-0.28 ‒ 0.35
-0.044 ‒
-0.32 ‒ 0.38
0.0074
-0.61 ‒
-0.13 ‒ 0.13 -0.61 ‒ 0.11
-0.29 ‒ 0.33 -0.30 ‒ 0.32 -0.17 ‒ 0.47 -0.30 ‒ 0.37
Corrected for age
-0.10 ‒ -0.020 **
-0.30 ‒ 0.34 -0.047 ‒ 0.012 -0.14 ‒ 0.75
-0.89 ‒ -0.051 *
-0.13 ‒ 0.15 6 -0.57 ‒ 0.29
-0.33 ‒ 0.33
-0.34 ‒ 0.32 -0.15 ‒ 0.50 -0.26 ‒ 0.45
0.036
AMH = anti-Müllerian hormone (in ug/L), RF = rheumatoid factor, ACPA = anti-citrullinated protein antibodies, DAS28- CRP = disease activity score with a 28 joint count and C-reactive protein, NSAIDs = non-steroidal anti-inflammatory drugs.
* p<0.05 ; ** p<0.01
DISCUSSION
In female RA patients trying to conceive, we found that preconceptional serum AMH levels, corrected for age, were lower than those in healthy controls. AMH levels were signi cantly negatively associated with ACPA positive disease. Serum AMH levels did not show a signi cant association with the TTP in RA patients, not even when used as a substitute for age.
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