Page 113 - Fertility in Women with Rheumatoid Arthritis Vruchtbaarheid van vrouwen met reumatoïde artritis

in ACPA positive patients versus ACPA negative patients, in RF positive patients versus RF negative patients, and in patients with erosions at baseline versus those without erosions at baseline. However, these differences were not statistically signi cant.
Table 3 – Distribution of age-speci c percentiles of serum AMH levels in women with rheumatoid arthritis from the PARA study, grouped by serology and erosions
AMH in RA – longitudinal
ACPA$
Pos
(n=78)
13 (17%) 31 (40%) 30 (38%) 4 (5.1%)
35 (45%) 17 (22%) 20 (26%) 4 (5.1%) 2 (2.6%)
RF$
pos
(n=85)
15 (18%) 35 (41%) 31 (36%) 4 (4.7%)
38 (45%) 21 (25%) 23 (27%) 3 (3.5%) -
Erosions$,¶
neg
(n=50)
First AMH measurement
<P10 7 (14%) P10-P50 18 (36%) P50-P90 22 (44%) >P90 3 (6.0%)
Last AMH measurement
<P10 15 (30%) P10-P50 10 (20%) P50-P90 23 (46%) >P90 1 (2.0%) NA 1 (2.0%)
neg
(n=43)
5 (12%) 14 (33%) 21 (49%) 3 (7.0%)
12 (28%) 6 (14%) 20 (47%) 2 (4.7%) 3 (7.0%)
no
(n=48)
5 (10%) 17 (35%) 24 (50%) 2 (4.2%)
15 (31%) 11 (23%) 21 (44%) 1 (2.1%) -
Yes
(n=77)
15 (19%) 32 (42%) 26 (34%) 4 (5.2%)
34 (44%) 16 (21%) 20 (26%) 4 (5.2%) 3 (3.9%)
Values are given as n(%)
ACPA = anti-citrullinated protein antibodies, RF = rheumatoid factor, AMH = anti-Müllerian hormone $ at baseline
¶ the presence or absence of erosions were missing for n=3 subjects
Linear mixed model 7 For 1 patient 8 measurements were available, 4 patients had 7 measurements,
1 patient had 6 measurements, 13 patients had 5 measurements, 50 patients had
4 measurements, 15 patients had 3 measurements, and 44 patients had
2 measurements. The intra-individual mean time between the rst available AMH measurement and the last was 10.7 ± 1.8 years, with a range of 6.4 – 13.7 years. The mean age at the rst AMH measurement was 31.8 ± 3.8 years, and at the nal assessment 42.6 ± 4.4 years.
Repeated measurement analysis using a LMM showed a signi cant decrease of serum AMH levels with increasing age. None of the RA-related variables (disease duration, presence of ACPA, of RF, or of erosions, MTX use (ever)) did have a signi cant effect on the AMH levels over time in this group of 128 female RA patients (Table 4). Comparing
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