Page 111 - Fertility in Women with Rheumatoid Arthritis Vruchtbaarheid van vrouwen met reumatoïde artritis

Of the participants, 41 (32%) women reported amenorrhoea (i.e. no menstruation in the preceding 12 months). In 29 women this could be explained by continuous oral contraceptive use (n=3) or the presence of a hormonal intra-uterine device (n=26), and 1 woman had a lactational amenorrhoea. Seven women had had a hysterectomy. In 4 women (3.1%) the amenorrhoea could not be explained by other causes, and they were considered postmenopausal. Their menopause had been at an age of 39, 44, 44 and 45 years respectively. Three of them had AMH values below the LoD, and in 1 patient the serum AMH level was 0.0114 ug/L.
Table 2 - Comparison of participants and non-participants in the follow-up of the PARA study
AMH in RA – longitudinal
Current study
n=128 42.5 ± 4.4 32.0 ± 3.9
9 (7%) 2 (2%)
98 (77%) 24 (19%) 6 (5%)
-
73 (57%) 117 (91%) 6 (4.7%)
15.6 (12.6 -
4.2 (2.0 - -
78 (61%) 86 (67%) 77 (60%) 3 (2.3%)
Non-participants
n=167
P value
Number of unique patients
Age¶ - years
Age at last PARA episode - years
Smoker during PARA study missing
Number of episodes within PARA study 1 episode
2 episodes 3 episodes 4 episodes
Obstetric history
Never pregnant before PARA study Pregnant during last PARA episode
Nulliparous at end of PARA study Disease Characteristics
Duration of RA¶ - years missing
Duration of RA at rst PARA episode missing
Presence of ACPA Presence of RF Presence of erosions
- 20.9) 9.6)
43.4 ± 4.1 0.055§ 32.8 ± 3.9 0.11§
28 (17%) 0.013† 4 (2%)
139 (83%) 24 (14%) 3 (2%)
1 (1%)
93 (56%) 0.91† 120 (72%) <0.001† 36 (22%) <0.001†
15.5 (13.1 - 20.5) 0.88‡ 2 (1%)
4.7 (1.9 - 8.5) 0.99‡ 2 (1%)
112 (67%) 0.33† 125 (75%) 0.16† 100 (60%) 0.61† 9 (6.4%)
3.8 ± 1.2 0.17§ 54 (32%)
3.6 ± 1.2 0.57§ 70 (42%)
3.5 ± 1.2 0.79§ 4 (2%)
7
missing
Disease activity Score (DAS28) during last PARA episode
Preconception missing
First trimester missing
last available DAS28 (non-pregnant) missing
3.6 ± 1.3 51(40%) 3.5 ± 1.2 37 (29%) 3.5 ± 1.2 -
† Fisher's exact test; ‡ Mann-Whitney U test; § Student's t test ¶ at January 1st 2016
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