Page 169 - Molecular features of low-grade developmental brain tumours

MIR-519D & MIR-4758 CAN IDENTIFY GG FROM DNT AND ASTROCYTOMAS
References
1. Blumcke, I. et al. Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification. Nature reviews. Neurology 12, 732-740, doi:10.1038/nrneurol.2016.173 (2016).
2. Blumcke, I., Aronica, E., Urbach, H., Alexopoulos, A. & Gonzalez-Martinez, J. A. A neuropathology- based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors. Acta neuropathologica 128, 39-54, doi:10.1007/ s00401-014-1288-9 (2014).
3. Thom, M., Blumcke, I. & Aronica, E. Long-term epilepsy-associated tumors. Brain pathology (Zurich, Switzerland) 22, 350-379, doi:10.1111/j.1750-3639.2012.00582.x (2012).
4. Blumcke, I. et al. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. N Engl J Med 377, 1648-1656, doi:10.1056/NEJMoa1703784 (2017).
5. Luyken, C. et al. The spectrum of long-term epilepsy-associated tumors: long-term seizure and tumor outcome and neurosurgical aspects. Epilepsia 44, 822-830 (2003).
6. Faramand, A. M. et al. Seizure and cognitive outcomes after resection of glioneuronal tumors in children. Epilepsia 59, 170-178, doi:10.1111/epi.13961 (2018).
7. Louis, D. N. et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta neuropathologica 131, 803-820, doi:10.1007/s00401-016-1545-1 (2016).
8. Schindler, G. et al. Analysis of BRAFV600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta neuropathologica 121, 397-405, doi:10.1007/s00401-011-0802-6 (2011).
9. Rivera, B. et al. Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors. Acta neuropathologica 131, 847-863, doi:10.1007/s00401-016-1549-x (2016).
10. Aronica, E. & Crino, P. B. Epilepsy related to developmental tumors and malformations of cortical development. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 11, 251-268, doi:10.1007/s13311-013-0251-0 (2014).
11. Boer, K. et al. Pi3K-mTOR signaling and AMOG expression in epilepsy-associated glioneuronal tumors. Brain pathology (Zurich, Switzerland) 20, 234-244, doi:10.1111/j.1750-3639.2009.00268.x (2010).
12. Koelsche, C. et al. Mutant BRAFV600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells. Acta neuropathologica 125, 891-900, doi:10.1007/s00401-013-1100-2 (2013).
13. Prabowo, A. S. et al. BRAFV600E mutation is associated with mTOR signaling activation in glioneuronal
tumors. Brain pathology (Zurich, Switzerland) 24, 52-66, doi:10.1111/bpa.12081 (2014).
14. Dahiya, S. et al. BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma. Acta
neuropathologica 125, 901-910, doi:10.1007/s00401-013-1120-y (2013).
15. Lee, D. et al. BRAFV600E mutations are frequent in dysembryoplastic neuroepithelial tumors and
subependymal giant cell astrocytomas. J Surg Oncol 111, 359-364, doi:10.1002/jso.23822 (2015).
16. Chappe, C. et al. Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. Brain pathology
(Zurich, Switzerland) 23, 574-583, doi:10.1111/bpa.12048 (2013).
17. Huse, J. T. et al. Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an
epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway. Acta neuropathologica 133, 417-429, doi:10.1007/s00401-016-1639-9 (2017).
18. Thom, M. et al. Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?
167
6