Page 159 - Molecular features of low-grade developmental brain tumours

Duration of Pre-operative seizure Post-operative out- epilepsy (years) freq. (per month) come (Engel’s score)
Mutation
6
MIR-519D & MIR-4758 CAN IDENTIFY GG FROM DNT AND ASTROCYTOMAS
16 200 1 3 56 1 2 30 1
31 60 1 8 70 2 3 55 1 0 3 1 9 60 1 4 70 1 5 20 1 0 80 1
23 90 1
9 160 1
30 150 1
16 30 2
1 30 1
1 <5 1
24 10 1
3 10-20 1
41 >30 1
-- -- --
15 -- 1
12 -- 1
-- -- --
22 <5 1
4 80-100 2
4 >50 1
22 <5 1
1 10-20 1
6 >30 1
5 5-10 4
3 10-20 1
2 <5 1
18 >30 1
10 >50 1
BRAFV600E BRAFV600E BRAFV600E
NMI
BRAFV600E
BRAF T559R and BRAFV600E* BRAFV600E
BRAFV600E
NMI
BRAFV600E
BRAFV600E
NMI
BRAFV600E
BRAFV600E
BRAFV600E
BRAFV600E
NMI
NMI
NMI
NMI
NMI
NMI
NMI
BRAFV600E
BRAFV600E
BRAFV600E
NMI
NMI
Mutation unknown
NMI
BRAFV600E
CIC G935R
NMI
FGFR1 G539R and FGFR1 K656E
NMI
*Both mutations are on the same allel. F frontal, T temporal, P parietal, B brainstem, C cerebellum, NMI no mutation identified.
157