Page 125 - Molecular features of low-grade developmental brain tumours

Chapter five
Dysregulation of the MMP/TIMP proteolytic system in subependymal giant cell astrocytomas in patients With tuberous sclerosis complex: modulation of MMP by microRNA-320d in vitro
Bongaarts A1*, de Jong JM1*, Broekaart DWM1*, van Scheppingen J1, Anink JJ1, Mijnsbergen C1, Jansen FE2, Spliet WGM3, den Dunnen WFA4, Gruber VE5, Scholl T5, Hainfellner JA6, Feucht M5, Borkowska J7, Kotulska K7, Jozwiak S7,8, Grajkowska W9, Buccoliero AM10, Caporalini C10, Giordano F11, Genitori L11, Scicluna BP12, Schouten-van Meeteren AYN13,14, van Vliet EA1,15, Mühlebner A1, Mills JD1†, Aronica E1,16†
1. Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. 2. Department of Pediatric Neurology, University Medical Center Utrecht brain center, The Netherlands. 3. Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. 4. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 5. Department of Pediatrics, Medical University of Vienna, Vienna, Austria. 6. Institute of Neurology, Medical University of Vienna, Vienna, Austria. 7. Department of Neurology and Epileptology, Children’s Memorial Health Institute, Warsaw, Poland. 8. Department of Child Neurology, Medical University of Warsaw, Warsaw, Poland. 9. Department of Pathology, Children’s Memorial Health Institute, Warsaw, Poland. 10. Pathology Unit, Anna Meyer Children’s Hospital, Florence, Italy. 11. Department of Neurosurgery, Anna Meyer Children’s Hospital, Florence, Italy. 12. Amsterdam UMC, University of Amsterdam, Center for Experimental & Molecular Medicine and Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Amsterdam, The Netherlands. 13. Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. 14. Amsterdam UMC, University of Amsterdam, Department of Pediatric Oncology, Emma Children’s Hospital, Amsterdam, The Netherlands. 15. Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands. 16. Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands. *Authors contributed equally to the present work. †These authors share senior authorship
J Neuropathol Exp Neurol. 2020 Jul; 79(7): 777–790