Page 60 - Predicting survival in patients with spinal bone metastasesL

CHAPTER IV
Table 4. Results of the uni- and multivariate analyses. HR: hazard ratio. CI: confidence interval. C: cervical.
CT: cervicothoracic. T: thoracic. TL: thoracolumbar. L: lumbar. D: diffuse.
Univariate log-rank test
p-value
Clinical profile (Favorable/Moderate/Unfavorable) Karnofsky (100-80/70-10)
Frankel classification (ABC/D/E)
Visceral metastases (Yes/No)
Brain metastases (Yes/No)
Number spinal metastases (1/2/≥3) Extra-spinal metastases (0/1/≥2)
Location spinal metastases (C/CT/T/TL/L/D)
Clinical profile Favorable Moderate Unfavorable
Performance status Normal (100-80) Impaired (70-10)
Visceral metastases Not present Present
- 1.6 3.5
- 1.9
- 1.5
- 1.3-2.1 2.9-4.4
- 1.6-2.2
- 1.3-1.7
<0.001 <0.001 <0.001 <0.001 0.012 0.983 0.093 0.836
<0.001 <0.001 <0.001
<0.001 <0.001
<0.001 <0.001
Multivariate Cox-regression model
HR
95%CI
p-value
Table 5. Results of the uni- and multivariate analyses stratified for clinical profile. HR: hazard ratio. CI: confidence interval.
Univariate analysis
Favorable (n=312)
Moderate (n=296)
Unfavorable (n=435)
Performance status Visceral metastases
Brain metastases
Frankel classification Number spinal metastases Bone metastases
Location spinal metastases
Model 1: Favorable profile
Performance status ≤70 Visceral metastases present Brain metastases present
Model 2: Moderate profile
Performance status ≤70
Model 3: Unfavorable profile
Performance status ≤70
<0.001 <0.001 <0.001 0.086 0.009 0.482 0.043 0.757 0.054 0.469 0.078 0.120 0.657 0.196
1.7 1.3-2.2 2.0 1.5-2.7 1.8 1.1-3.0
2.3 1.7-2.9 1.9 1.5-2.3
<0.001 0.165 0.528 0.248 0.243 0.943 0.867
<0.001 <0.001 0.016
<0.001 <0.001
Cox-regression models
HR
95% CI
p-value
Analysis stratified for clinical profile
Results of the univariate and multivariate analyses for the three clinical profiles are illustrated in table 5. A poor KPS (HR 1.7, 95%CI 1.3-2.2, p<0.001), the presence of visceral metastases (HR 2.0, 95%CI 1.5-2.7, p<0.001) and the presence of brain
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