Page 59 - Predicting survival in patients with spinal bone metastasesL
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PREDICTIVE MODEL
Figure 2. Survival curves of clinical profiles. Table 3. Treatment details.
Overall
Radiotherapy only Surgery and radiotherapy Surgery only
Radiotherapy regimens
1x8 Gy
2x8 Gy
6x4 Gy or 5x4 Gy
Other – Total dose >24 Gy
Surgery
Minimal invasive
Limited decompression and fixation Extended decompression and fixation
Analysis of the entire cohort
997 (95) 39 (4) 7 (1)
445 (43) 169 (16) 322 (31) 100 (10)
10 (22) 23 (50) 13 (28)
IV
Treatment
N (%)
Results of the univariate and multivariate analyses are detailed in table 4. The three clinical profiles (moderate HR1.6, 95%CI 1.3-2.1, p<0.001) (unfavorable HR3.5, 95%CI 2.9-4.4, p<0.001), the KPS (HR1.9, 95%CI 1.6-2.2, p<0.001) and the presence of visceral metastases (HR1.5, 95%CI 1.3-1.7, p<0.001) were shown to be of influence on survival. The Frankel classification, the number and location of the spinal metastases and the presence of brain and extraspinal bone metastases did not influence survival.
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