Page 27 - Predicting survival in patients with spinal bone metastasesL

Table 2. Level of evidence for investigated prognostic factors. Numbers refer to study identification from table 1. ASA: American Society of Anesthesiologists. SBM: spinal bone metastases. Studies with a low risk of bias are in bold.
Primary tumor
Performance status
ASA classification
Age
Gender
Number SBM Location SBM
Pathologic fracture
Visceral metastases
Neurologic deficit
Interval diagnosis
Extraspinal bone metastases
Number bone metastases
Pain
Sphincter function
Weight loss
Cardiovascular disease
DISCUSSION
Strong – 86%
Strong – 93%
Strong – 100%
Strong – 80%
Strong – 79%
Strong – 91%
Strong – 89% Strong – 100%
Inconclusive – 73% Inconclusive – 57% Inconclusive – 67% Inconclusive – 63%
Inconclusive – 50%
Inconclusive – 67% Inconclusive – 67%
Inconclusive – 50% Inconclusive – 50%
II
2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 17, 18, 20, 21, 22
2, 3, 8, 9, 11, 12, 13, 17, 18, 19, 20, 21, 22
11,19
6, 9, 13
2, 8, 18
21
8
3, 9, 12, 14, 15, 17, 18, 19, 20,
21, 22
1, 4, 5, 7, 18, 21
1, 13, 14, 18 14, 17, 18
9,15 4,11
5
11 11
13, 16, 19 14
2, 7, 10, 11, 12, 14, 15, 16, 17, 18, 19, 22
7, 9, 10, 11, 12, 13, 14, 16, 17, 19, 22
2, 11, 12, 14, 16, 17, 18, 19, 20, 22 2, 7, 10, 11, 16, 19, 20, 22 7,11,12
2, 7, 11, 13
2, 12, 14, 16, 17, 19, 20, 22 15, 16
12, 19, 20, 21, 22
3,21 14
7,11 19
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SYSTEMATIC REVIEW
Prognostic factor
Positive association
No association
Level of evidence
In this systematic review it is shown that the primary tumor, performance status and the ASA classification are associated with survival in patients with spinal bone metastases. Age, gender, number of SBM, location of SBM and the presence of a pathologic fracture are most likely not associated with survival.
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