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Parkinsonism in GNDs672Figure S2. continued0-24$-49P-74u-100%Genetic conditionNumber of casesMale *Intellectual disability *Mean age at motor onsetBradykinesia, hypokinesia or akinesia *Rigidity *Rest tremor *Postural instability *Asymmetric motor symptoms *Progression of motor signs *Reduced DAT binding with dopaminergic imagingGood response antiparkinsonian medication *Levodopa-induced dyskinesia *Cognitive decline/ Psychiatric symptomsProposed main cause of parkinsonism: Parkinson’s disease Genetic Drug-inducedCo-existing neurologic disorder: Epilepsy/seizures Dystonia Ataxia OtherDopa-responsive dystonia (GCH1) 4 2/4 0/4 40 3/3 2/2 2/2 1/1 1/2 2/2 1/1 3/3 2/3 1 0 - - - - 2/4 0 2 0 0Dystonia 16 (PRKRA) 4 3/4 0/4 11 3/3 1/1 1/1 - 3/3 3/3 - 0/3 - 0 0 - - - - 4/4 0 4 0 0Glutaric aciduria type 1 4 3/4 - <214/4 4/4 - - - - - - - 0 0 - - - - 4/4 0 4 0 1Phenylketonuria (PAH) 4 1/4 3/4 34 4/4 3/4 3/3 1/1 1/1 1/2 1/2 3/3 0/2 0 0 2/4 1 1 0 1/4 1 0 0 0PPP2R5D 4 2/4 4/4 27 3/3 3/3 3/4 2/2 3/3 4/4 2/2 4/4 1/4 1 2 4/4 0 4 0 4/4 1 2 0 2Leigh syndrome (MT-ATP6 and MT-MFT)3 1/3 1/3 31 2/2 2/2 2/3 0/1 0/1 3/3 1/1 0/2 - 0 1 2/3 1 1 0 3/3 2 1 1 1Menkes disease (ATP7A) 3 0/3 1/1 50 - - 1/1 - 3/3 - 1/1 0/2 - 0 0 3/3 0 3 0 1/3 1 0 0 0Dopa-responsive dystonia, Sepiapterin reductase deficiency (SR) 2 2/2 1/2 15 1/1 1/1 1/2 - 1/1 2/2 - 2/2 2/2 0 0 1/1 0 1 0 2/2 1 2 0 1Early infantile epileptic encephalopathy 4 (STXBP1)2 0/2 2/2 9 2/2 2/2 2/2 1/1 2/2 2/2 - - - 0 0 2/2 0 2 0 2/2 2 1 1 2L2-hydroxyglutaric aciduria (L2HGDH)2 1/2 0/1 38 2/2 2/2 1/2 2/2 1/2 2/2 1/1 1/2 0/1 1 0 2/2 1 1 0 2/2 0 1 1 1SPG10 (KIF5A) 2 0/2 0/2 55 2/2 1/1 1/2 - 2/2 1/1 - 1/1 - 0 0 - - - - 1/2 0 0 0 1WARS2 f 2 2/2 0/1 1 1/1 0/1 2/2 1/1 1/1 2/2 1/1 2/2 1/1 0 0 1/1 0 1 0 2/2 0 2 0 1X-linked adrenoleukodystrophy (ABCD1)2 2/2 0/2 58 1/1 1/1 0/1 - 1/1 1/1 1/1 1/1 - 0 0 1/1 1 0 0 1/2 0 0 0 15,10-methylenetetrahydrofo,late reductase deficiency1 0/1 - 2 1/1 1/1 1/1 - - 1/1 1/1 - 0/1 0 0 - - - - 1/1 0 0 1 0Argininosuccinate Lyase Deficiency g1 0/1 1/1 61 1/1 1/1 1/1 1/1 0/1 - - - - 0 0 - - - - 1/1 0 0 1 1CLTC h 1 0/1 1/1 4 1/1 1/1 0/1 - - 1/1 0/1 0/1 - 0 1 1/1 0 1 0 1/1 0 0 1 1Cornelia de Lange syndrome1 1/1 1/1 30 1/1 1/1 0/1 1/1 0/1 1/1 - 1/1 0/1 0 0 - - - - 1/1 1 1 0 1Cowden syndrome (PTEN) 1 0/1 0/1 66 - - - - - - - - - 0 1 1/1 1 0 0 0/1 0 0 0 0MT-CYB 1 1/1 0/1 15 1/1 1/1 1/1 1/1 1/1 1/1 - - - 0 0 - - - - 1/1 1 0 0 1DOORS syndrome (ATP6V1B2)1 1/1 1/1 63 - 1/1 1/1 - 1/1 1/1 - 0/1 - 0 1 0/1 1/1 1 0 0 1Dopamine transporter deficiency syndrome (SLC6A3)1 - - 0.5 1/1 1/1 0/1 0/1 - 1/1 - - - 0 0 1/1 0 1 0 1/1 0 1 0 1Early-onset Lafora disease (EPM2A)1 0/1 0/1 14 1/1 1/1 1/1 - - 1/1 - - - 1 0 - - - - 1/1 1 0 0 1HSD10 (HSD17B10) 1 0/1 1/1 17 1/1 1/1 0/1 - 1/1 1/1 1/1 - - 1 1 - - - - 0/1 0 0 0 0Incontinentia Pigmenti (IKBKG) 1 0/1 0/1 48 1/1 - - - 1/1 1/1 1/1 1/1 - 1 0 1/1 0 1 0 0/1 0 0 0 0Leigh-like syndrome (MT-TI) 1 1/1 - 16 1/1 1/1 0/1 - - 1/1 - 1/1 - 1 1 - - - - 0/1 0 0 0 0