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Chapter 258sMethods 1. Search strategy DescriptionGeneral search terms related to “genetic disease”, “neurodevelopmental disorder” and “Parkinson’s disease/parkinsonism” were included in the search. Mesh terms in the first subheading of “genetic disease, inborn” were included if they have been associated with a neurodevelopmental disorder. General search terms were combined with a list of genetic disorders associated with a neurodevelopmental abnormality. This list of search terms was composed using the human phenotype ontology (HPO) database on http://www.orphadata.org/cgi-bin/index.php. All terms describing a rare genetic disease assigned to the subontology neurodevelopmental abnormality, defined by HPO as ‘A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities’ were included; collectively, the ‘HPO/ND-list’.PubMedGeneral search termsParkinson/parkinsonism“Parkinsonian Disorders”[Mesh] OR Parkinson*[tiab] OR “lewy body dementia”[tiab] OR lewy body disease*[tiab]ANDGenetic disease/neurodevelopemental disorder“Genetic Diseases, Inborn”[Mesh:NoExp] OR genetic disease*[tiab] OR genetic disorder*[tiab] OR hereditary disease*[tiab] OR hereditary disorder*[tiab] OR single-gene defect*[tiab] OR “Chromosome Disorders”[Mesh] OR chromosome disorder*[tiab] OR chromosomal disorder*[tiab] OR “Metabolism, Inborn Errors”[Mesh] OR inborn error metabolism*[tiab] OR inborn metabolism error*[tiab] OR “Intellectual Disability”[Mesh] OR intellectual disabilit*[tiab] OR mental retardation*[tiab] OR Intellectual Development Disorder*[tiab] OR Intellectual Developmental Disorder*[tiab] OR mental deficienc*[tiab] OR neurodevelopmental delay[tiab] OR neurodevelopment delay[tiab] OR “Alagille Syndrome”[Mesh] OR syndrome