Page 139 - Demo

Hearing loss and otolaryngological conditions1374ResultsDemographics Sixty adults (25 male, 41.7%) with 22q11.2DS were included. The median age at audiometry was 24.5 (range 16-62) years and the median age at otolaryngologic examination was 25.0 (range 16-74) years. Mean FSIQ scores, available for 57 adults, were 65.3±11.1 at median age 23.0 (range 13-57) years.Table 2. Hearing loss in 60 adults with 22q11.2 deletion syndromePrevalence of hearing loss number % 95% CIHearing loss, ≥ 1 ear aHearing loss, better-hearing ear a limited to high-frequencies (2) Mild (2a) Moderate (2b) Severe (2c) Corrigible with hearing aids (3) Mild (3a) Moderate (3b) Severe (3c)473925167214121178.365.041.726.711.74.323.320.01.71.767.9 – 88.852.9 – 77.129.2 – 54.115.5 – 37.93.5 – 19.80.0 – 7.912.6 – 34.09.9 – 30.10.0 – 4.90.0 – 4.9Laterality of hearing lossBilateral, symmetricalBilateral, asymmetricalUnilateral2415840.025.013.327.6 – 52.414.0 – 36.04.7 – 21.9 Type of hearing loss bSensorineuralConductiveMixedUndefined c14521835.912.85.146.220.8 – 51.02.3 – 23.30.0 – 12.130.5 – 61.8Audiometric configurationFlatHigh-frequency steeply sloping High-frequency gently slopingMid-frequency n-shapedLow-frequency ascending2714117145.023.318.311.71.732.4 – 57.612.6 – 34.08.5 – 28.13.5 – 19.80.0 – 4.9a severity according to the Muenster classification.12b Proportions of a total of 39 adults with hearing loss of the better-hearing ear.c Hearing loss limited to the high-frequencies could often not be classified due to missing boneconduction thresholds at 6 and 8 kHz.CI=confidence interval.AudiometryTable 2 shows data on audiological assessments. Hearing loss in at least one ear was found in 47 adults (78.3%) of whom 8 had unilateral hearing loss. Of the better-hearing ear, 39 adults (65.0%) showed hearing loss that was mostly limited to the high-frequencies (n=25, 41.7%). In 14 adults (23.3%) more severe hearing loss was found that also included loss at the