Page 83 - Coronary hemodynamics in acute myocardial infarction - Matthijs Bax

Variable
Reference vessel CFVR <2.1 Infarct-related artery CFVR <1.5
Hazard Ratio
3.67 1.67
95% confidence interval
1.19 – 11.37 0.56 – 4.98
P Value
0.02 0.36
Coronary microvascular function and long-term mortality
Table 2. Bivariate Analysis of the Association Between CFVR in Reference and Target Vessels, and Long- term Cardiac Mortality
No significant interaction was present (P value for interaction=0.93). CFVR indicates coronary flow velocity reserve.
Table 3. Baseline Clinical and Hemodynamic Characteristics (n=94)
Reference Vessel CFVR
Demographics Age, y
Male Risk factors
Smoking Hypertension Family History Hyperlipidemia Diabetes Mellitus
Prior medication use β-Blocker
Calcium antagonist Angiotensin-converting enzyme inhibitors Nitrates
Lipid Lowering Drugs
Aspirin
Laboratory assessments at admission CRP, mg/L
Glucose, mmol/L
eGFR, mL/min
NT-proBNP after reperfusion, pg/ml Peak CK-MB during hospitalization, μg/L
Procedural characteristics Heart rate, BPM
Systolic arterial pressure, mmHg
WMSI prior to reperfusion
Time to reperfusion, hours
ST-Segment resolution after reperfusion ≥70%
Angiographic and Doppler characteristics Final TIMI flow grade 3
Final myocardial blush grade 3 Final IRA CFVR
Baseline APV, cm/s Hyperemic APV, cm/s
≥2.1 (n=61)
53±11 52 (85)
30 (49) 14 (23) 27 (44) 15 (25) 4 (7)
6 (10) 2 (3) 3 (5) 3 (5) 4 (7) 4 (7)
1.9 (1.1–3.8) 7.4 (6.7–9.0) 109±26
75 (44–157) 401 (231–613)
78±13 119±13 1.8±0.2 2.8 (2.2–3.9) 27 (44)
50 (82) 33 (54) 1.7±0.4 20±9 34±16
<2.1 (n=33) P Value
61±12 0.002 27 (82) 0.67
21 (64) 0.07 5 13 (40) 0.07
11 (33) 0.32
10 (30) 0.49
2 (6) 0.97
7 (21) 0.21 5 (15) 0.09 1 (3) 0.64 1 (3) 0.64 3 (9) 0.70 7 (21) 0.05
4.5 (1.4–8.1) 0.02 7.5 (6.8–9.8) 0.40 103±30 0.29 166 (69–311) 0.02
630 (410–778) 0.001
86±13 0.01 121±19 0.58 2.0±0.2 0.03
3.0 (2.3–3.5) 0.51 12 (36) 0.14
20 (61) 0.06 16 (49) 0.82 1.4±0.3 <0.001
21±9 0.76 29±13 0.12
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