Page 77 - SPONDYLOARTHRITIS IN COLOMBIA -

The malignancies found in SpA patients in men were: prostate-cancer (n=2), skin-cancer (n=2), colon-cancer (n=1); and in women: cervix-cancer (n=2), breast-cancer (n=2) and skin-cancer (n=2). The majority of cases had been reported in patients ≥50 years of both genders, (7 cases in Argentina, 3 cases in Colombia and one case in Mexico). The overall prevalence of malignancies observed in the three LA countries was 2.8% (95%CI 1.4 to 5.1), which was slightly lower than the prevalence in the global ASAS-COMOSPA-study (3.2%, 95%CI 2.6 to 3.8) and not significantly increased in comparison to the general-population (2.6%) (p=0.5). The SRR for malignancies was 1.0. There was not a significant increase in the prevalence and the risk to develop malignancies in patients with SpA compared with the general-population (Table-4).
Table 4. Observed prevalence of all malignancies in the ASAS-COMOSPA study (Latin America) compared with the expected prevalence in general population and prevalence of Global ASAS-COMOSPA for reference.
Observed
LA ASAS-COMOSPA
N (%) 0 0
0 0
0 0
1 5.0 1 7.6 1 7.1 1 8.3 1 7.6 5 2.0
0 0
0 0
1 4.3 2 15.3 2 13.3 1 8.3 0 0
0 0
6 4.2
Expected General population
Prevalence (%) 0.41 0.76 1.29 2.39 4.11 6.49 9.28 15.17 2.41
0.54 1.91 2.70 3.53 4.49 5.90 6.98 9.57 2.67
SRR (CI 95%) Global ASAS-COMOSPA
Gender Men
Age groups 20-39 40-44 45-49 50-54 55-59 60-64 65-70
≥70
Total men
20-39
40-44
45-49
50-54
55-59
60-64
65-70
≥70
Total women
- - -
2.0 1.8 1.0 0.8 0.5
0.8 (0.3-1.9)
-
- 1.5 4.3 2.9 1.4 - - 1.5 (0.7-3.4)
1.0 (0.6-1.9)
n (%) 4 0.3
2 0.6 5 1.6 8 3.0 9 3.9 9 5.4 13 11.3 27 21.9
77 2.9
6 1.2 3 1.6 4 2.2
11 6.0 6 4.6
10 10.0 4 4.8 7 10.7
51 3.6 128 3.2
Women
Total (men /women)
11 2.8 2.6
n=number with a diagnosis of malignancies in each gender and age group. Prevalence (%). SRR: Standardized risk ratio; LA*, Latin America
75