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Evolution of usage of domains and instruments over time
In order to illustrate the evolution of the representation of domains and instruments, figures 2a and 2b were constructed. An increasing usage of domains and instruments was found over time. Looking at the results, the increased usage was primarily attributable to the advent of RCTs testing biological drugs shortly after the year 2001. We did not find an important increase in usage of domains over time in RCTs with NSAIDs, DMARDs or miscellaneous interventions, but the number of ASAS core-set instruments per RCT increased not only in biological drugs RCTs but also in RCTs with miscellaneous interventions.
Figure 2a Dot plot illustrating the number of ASAS core set domains per trial according to the date of publication and type of intervention. Miscellaneous interventions in this context, include physical therapy and other kind of treatments. Glucocorticoids are included in DMARDs interventions. All studies (n=99).
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