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extracted; including the response criteria ASAS20 7, ASAS40 8, ASAS5/6 and BASDAI50, and the disease state ASAS partial remission.
Table 1 Assessment of SpondyloArthritis international Society (ASAS)/Outcome in Rheumatology (OMERACT) core set for symptom modifying anti-rheumatic drugs (SMARD), disease-controlling anti-rheumatic treatments (DC-ART) and specific instruments for each domain.
Domains
Instruments
van der Heijde, 1999
Index (DFI) [10]
VAS, last week, spine, at night, due to AS
VAS, last week, spine, due to AS Chest expansion [11], modified Schober test [12], occiput to wall distance
Duration of morning stiffness, spine, last week
VAS last week
Number of swollen joints (44-joint count), no instrument for entheses
ESR
AP/lat lumbar and lat cervical spine and X-pelvis (SI and hips)
No preferred instrument
Instruments
ASAS Handbook, 2009
BASFI
NRS/VAS (last week/spine/night/due to AS)
NRS/VAS (last week/spine/due to AS) Chest expansion, modified Schober, occiput to wall, cervical rotation, (lateral spinal flexion or BASMI) [13] NRS/VAS (duration of morning stiffness, spine, last week)
NRS/VAS (global disease activity last week)
Number of swollen joints (44 joint count) MASES [14], San Francisco or Berlin
CRP or ESR
mSASSS [15] on lateral lumbar spine / lateral cervical spine
Fatigue question BASDAI [16]
BASFI [9] or Dougados Functional
Function Pain
Spinal mobility
Spinal stiffness
Patient global
Peripheral joint, entheses
Acute phase reactants Radiograph spine
Fatigue
BASDAI, Bath Ankylosing Spondylitis Functional Index; NRS, Numerical Rating Scale; VAS, Visual Analogue Scale; BASMI, Bath Ankylosing Spondylitis Metrology Index; MASES, Maastricht Ankylosing Spondylitis Enthesis Score; CRP, C-reactive protein; ESR, Erythrocyte Sedimentation Rate; mSASSS, modified Stoke Ankylosing Spondylitis Spinal Score; BASRI, Bath Ankylosing Spondylitis Radiology Index; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index.
Data Analysis
First, all information retrieved from multiple articles but belonging to the same RCT was combined and considered as one RCT for the analysis. The datasets were analyzed to compare the use of the outcome measures in RCTs before and after the publication of the core-set.
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