Page 109 - Helicobacter pylori and Gastric Cancer: From Tumor microenvironment to Immunotherapy

the correlation between endoscopic evaluation and histological final diagnosis has been relatively underexplored. Generally speaking published studies support that endoscopic evaluation performs well with respect to the detection of histological IM and AG[18, 19]. However, these studies were performed in specific east-Asian high risk cohorts and the extent as to which these results can be extrapolated to the global situation remains uncertain, Data in patients specifically following H. pylori eradication are not present at all. Thus there is paucity in studies assessing the accuracy of endoscopic detection of AG in different settings.
The above mentioned considerations prompted us to investigate the concordance between histological diagnosis and endoscopic diagnosis employing the Kimura- Takemoto Classification of AG in a variety of geographical settings. The results show that irrespective of the context endoscopic evaluation performs well.
MATERIALS AND METHODS
Study population
The study population consisted of a total of 248 (Nigeria-cohort: 124, Iran-cohort: 124) patients who underwent both upper gastrointestinal Zoom endoscopy and examination for detection of H. pylori. The Nigeria cohort was collected at the University of Abuja Teaching Hospital, Gwagwalada. Abuja. Nigeria and the Iran cohort at the Department of Medical Laboratory Sciences. Marand Branch, Islamic Azad University, Marand, Iran. Only patients presenting between January 2007 and August, 2017 were evaluated in this study. Exclusion criteria were as follows: patients with prior history of gastrectomy, endoscopic evidence of reflux esophagitis, peptic ulcer disease, or malignancy and patients who had been treated with antibiotics, proton-pump inhibitors, bismuth-containing compounds or histamine H2 receptor blockers within four weeks before the endoscopic procedure. Patients were also excluded if they had received H. pylori eradication therapy in the past or had been treated with any non-steroidal anti-inflammatory drug in the two weeks leading up to the endoscopic procedure. The protocol was approved by the Ethics Committee of the University of Abuja Teaching Hospital, Gwagwalada. Abuja. Nigeria and Department of Medical Laboratory Sciences. Marand Branch, Islamic Azad University, Marand, Iran. All patients gave written informed consent before entering the study. Two-hundred and forty-eight patients satisfied the criteria,
Helicobacter Pylori
Helicobacter pylori
103
107
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