Page 29 - Physical activity in recipients of solid organ transplantation - Edwin J. van Adrichem
P. 29
Physical activity in recipients of solid organ transplantation
Table 1. Baseline characteristics (n=540) General characteristics
Age (yrs)
Gender male, n (%) Smoking, n (%)
Physical activity level [IQR] MET-min/day
Inactive tertile MET-min/day Moderate active tertile MET-min/day Active tertile MET-min/day Compliant to PA guideline, n (%)
Cardiovascular disease
Myocardial infarction, n (%)
Cardiac markers
MR-pro-ANP (pmol/L) NT-proBNP (pg/ml) Hs-TnT (μg/L)
Renal function eGFR
Creatinine clearance (ml/min)
Urinary protein excretion (g/24h) Dialysis time, months [IQR]
ltration rate.
min. max. 21 80
0.1 2139.4
0.1 94.1 23.7 330.0 124.5 2139.4
31.0 1440.0 19.4 15392.0 3 206
8.1 126.7 8 166 0.0 13.8 0 398
range 59
2139.3 94.0 306.3 2015.0
1409.0 15372.6 203
118.6 158 13.8 398
51.3 ± 12.2
294 (54) 217 (40)
117.1 [26.5; 294.3] 3.7 [0.1; 28.5] 117.1 [74.6; 226.1] 381.8 [234.0; 541.5] 281 (52)
43 (8) 29 (5)
162.0 [103.0; 268.0] 293.8 [131.4; 651.0] 0.014 [0.007; 0.024]
44.5 [33.4; 58.9] 61 [47; 77] 0.2 [0.0; 0.5] 27 [14; 49]
TIA
/ CVA,
n (%)
Re-transplantation, n (%)
MET, metabolic equivalent of tasks; PA, physical activity; TIA/CVA, Transient Ischemic Attack/
56 (10)
Cerebro Vascular Accident; MR-proANP, mid-regional pro-atrial natriuretic peptide; NT-proBNP, N-
terminal-pro brain natriuretic peptide; Hs-TnT, high sensitive troponine T; eGFR, estimated glomerular
Cardiac markers and mortality
In total, 117 RTR deceased (22%) of which 63 (54%) were due to CV causes. Univariate
Physical activity and mortality
Cox regression analyses showed that MR-proANP, NT-proBNP, and Hs-TnT were all
signi
cantly associated with both CV- and all-cause mortality (Table 2).
remained signi
cant in multivariable Cox regression models adjusted for age, gender, and
ese associations
eGFR. Further adjustment for PA level had only minimal in
uence on the association
between cardiac biomarker levels and mortality.
Low levels of PA were signi
cantly associated with both CV- and all-cause mortality in
RTR independent of age and gender (Model 2), history of CV events (Model 3), and
27.
2
