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Longitudinal changes of brain and behavior
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W2. Of the remaining 48 children (Figure S1), 43 participated in the MRI session. Two participants were excluded due to excessive head motion. The final reference group therefore consisted of 41 participants, with a mean age of 10.13 ± 0.71 (age range: 9.09-11.28, 63% boys).
Figure S1. Participant flowchart. minus reference group: 1 n=458, 2 n=343 Whole brain analyses reference group
Regions of interest were based on higher level group analyses of W2 in an independent reference group (the non-randomized dummy control group, n=41, Table S1). A full-factorial ANOVA with three levels (positive, negative and neutral feedback) was used to investigate the neural response to the social feedback event in the reference group. Results were False Discovery Rate (FDR) cluster corrected (pFDRcc<0.05), with a primary voxel-wise threshold of p<.005 (uncorrected) (Woo et al., 2014). We first investigated social feedback (positive, neutral, negative) versus fixation. This contrast resulted in activation in amongst others the fusiform gyrus, the inferior frontal gyrus, and the superior frontal gyrus (see Figure S2a and Table S1). In addition to the social feedback vs fixation contrast, we also investigated the specific conditions. The contrast Positive vs
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