Page 141 - The role of advanced echocardiography in patients with ischemic heart disease - Rachid Abou

135
7
Table 4. Univariable and multivariable Cox proportional hazard models for all-cause mortality
Age (per year)
Male gender
Systolic blood pressure (mmHg)
Hypertension
Diabetes mellitus
Hypercholesterolemia
Previous myocardial infarction
QRS duration (per ms)
Culprit vessel LAD
Multi-vessel disease
TIMI flow ≥2
Killip class ≥2
Peak Troponin levels,2μg/L
eGFR (ml/min/1.73m )
Body mass index, kg/m2
ACEi/ARBs 0.172 β-blockers 0.296
<0.001 1.067
1.051-1.083 <0.001 --- --- --- ---
Heart rate at discharge (per beat) Wall motion score index
Mitral regurgitation ≥2
LV ejection fraction (%)
1.023 2.366 2.830 0.956 1.005 1..160 1.026
0.364-1.067 0.997-1.019 0.382-1.196 0.900-2.219 0.957-0.993 0.996-1.005
0.085 0.152 0.179 0.133 0.006 0.871
LV mass index (per g/m2)
LV Global longitudinal strain (%) LV Mechanical dispersion (per ms)
1.026 0.969-1.087 0.382
Model Discrimination statistics
269 2336
HR 1.087
95% CI 1.073-1.101 0.911-1.697 0.996-1.007
p value <0.001 0.115 0.642 0.042 <0.001 0.988 0.010 <0.001 0.704 <0.001 0.009 <0.001 <0.001 <0.001 0.038 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 0.035 <0.001 <0.001
HR 1.071 --- --- 0.952 1.900 --- 0.997 1.009 --- 1.409 0.355 1.396 1.015 0.998 0.976 0.819 0.626 1.006 0.635 1.399 0.976 1.000 1.062 ---
95% CI 1.055-1.087 ---
--- 0.699-1.297 1.318-2.740 --- 0.588-1.622 1.001-1.017 --- 1.040-1.909 0.132-0.851 0.841-2.316 0.990-1.041 0.993-1.003 0.934-1.020 0.428-1.567 0.366-1.070 0.995-1.017 0.362-1.112 0.893-2.190 0.958-0.994 0.995-1.004 1.006-1.122 ---
p value HR 95% CI p value
1.266 1.001 1.319 2.294 0.997 1.701 1.019 0.951 1.990 0.367 2.909 1.051 0.987 0.960
---
---
Univariable
Baseline Model
Baseline Model + LVMD
1.010-1.724 1.655-3.180 0.722-1.378 1.138-2.544 1.013-1.026 0.733-1.234 1.518-2.608 0.173-0.778 1.966-4.305 1.032-1.070 0.983-0.992 0.924-0.998 0.116-0.256 0.206-0.425 1.014-1.031 1.559-3.590 1.964-4.076 0.943-0.970 1.000-1.009 1.117-1.204 1.021-1.031 Chi-square (χ2) -2 Log likelihood
--- 0.754 0.001 --- 0.928 0.027 --- 0.027 0.021 0.197 0.239 0.419 0.282 0.546 0.087 0.295 0.112 0.143 0.008 0.910 0.029 ---
--- 0.946 1.771 --- 0.956 1.008
0.695-1.289 0.727
2325**
ACE = angiotensin converting enzyme; ARB = angiotensin receptor blocker; CI = confidence interval; HR = hazard ratio; (e)GFR = glomerular filtration rate estimated with the Cockcroft-Gault formula; LAD = left anterior descending coronary artery ; LV= left ventricle; TIMI = thrombolysis in myocardial
infarction; *compared to baseline model p<0.001, **compared to baseline model p=0.001
1.221-2.568 --- 0.575-1.589
0.003 --- 0.862
0.999-1.016 0.071 --- --- ---
1.485 0.389 1.457 1.017 0.999 0.977 0.918 0.623 1.008 0.676 1.413 0.975 1.000
1.093-2.016 0.011 0.153-0.986 0.047 0.874-2.429 0.149 0.992-1.043 0.182 0.994-1.004 0.606 0.935-1.020 0.289 0.475-1.1775 0.800
1.012
1.005-1.018 0.001 290*