Page 122 - The role of advanced echocardiography in patients with ischemic heart disease - Rachid Abou

Chapter six. Layer-specific LV GLS and prognosis
On multivariable analysis, increasing age (HR=1.095; [95%CI; 1.068 to 1.123], p<0.001) and LV GLS at the epicardium (HR=1.085; [95%CI; 1.001 to 1.175], p=0.047) was independently associated with all-cause mortality (Table ).To determine the incremental value of LV layer-specific GLS on clinical and conventional echocardiographic parameters, global χ2 values were calculated using cox regression models (Table 5). The addition of layer-specific LV GLS to the baseline model resulted in a significant increase in χ2 values only for LV GLS at the epicardium (difference in χ2=+6; p=0.044) (Figure 3).
p = 0 .3 4 3
-2 Log likelihood 955
-2 Log likelihood 956
-2 Log likelihood 940
p = 0 .0 4 4 p = 0 .1 2 3
1 1 5
1 1 0
105
100
-2 Log likelihood 952
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Model1 Model2 Model3 Model4
Model 1: Clinical variables (Age, male gender, body mass index, heart rate at discharge, eGFR, Killip class 2,
m ultivessel disease) + echocardiographic variables (End-diastolic volum e at baseline, end-systolic volum e at baseline)
Model 2: model 1 + LV GLS endocardium Model 3: model 1 + LV GLS midmyocardium Model 4: model 1 + LV GLS epicardium
Figure 3. The incremental value of multilayer left ventricular global longitudinal strain over baseline clinical and echocardiographic variables associated with all-cause mortality.
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Chi-square