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Supplementary Figure 3
Proteasome subunit immu- noreactivity (β1, β1i β5 and
β5i) in mild MCD (mMCD) and in Alzheimer’ s disease (Alz). Panels A,C,E,G: mMCD. A: low β1expression (insert: high magnification of a neu- ron, with light nuclear expres- sion). C: low β1i expression (insert: high magnification of a neuron). E: nulclear expres- sion of β5 (arrows; neuron in insert). G: low β5i expression (neuron in insert). Panels B, D, F, H (Alz; hippocampus). B: β1 expression in neurons (CA1; arrows, cytoplasmic expres- sion) and around amyloid plaques (arrow-heads); D: β1i expression in glial cells (arrows, cytoplasmic expression). F: low β5 expression in neuronal cells (arrows). H: β5i expression in glial cells (arrows, cytoplasmic expression). Scale bar in B: A,C, F,G: 80 μm; B,D,H: 40 μm.
DYSREGULATION OF THE (IMMUNO)PROTEASOME PATHWAY IN MCD
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